Dm Test

The main purpose of the script is to detect the footprint of selection force in DNA methylation using SMP data. The underlying model of the test assumes the mutation rates among the cytosine sites of a locus following a gamma distribution, and requires the alpha parameter of the gamma distribution as the input. The, which requires the script, is for estimating the alpha value. See the -man/-help options for options and data preparation of the two scripts.




Jun Wang and Chuanzhu Fan. 2015. A neutrality test for detecting selection on DNA methylation using single methylation polymorphism frequency spectrum. Genome Biology and Evolution 7: 154-171.